Swapna Amod Patankar
Bharati Vidyapeeth Deemed University, India
Title: Human papilloma virus genotypes in the saliva samples of HIV sero-positive patients
Biography
Biography: Swapna Amod Patankar
Abstract
Introduction: Human Papilloma Virus (HPV) is a small circular double stranded DNA virus which has been implicated in a variety of benign and malignant neoplasias in human oral and anogenital regions. About 100 different HPV genotypes have been identified and classified as either low-risk or high-risk oncogenic types based on their ability to induce neoplasia in host epithelial cells. Most prevalent high-risk types are HPV 16 and 18, which have been detected in the majority of malignant lesions worldwide. Low-risk types such as HPV 6 and 11 are most often associated with benign lesions. Several epidemiological and molecular studies have suggested a significant link between high-risk HPV types (mainly 16 and 18) and oral cancer. Recent evidence has indicated that HPV-related pathology is increased in the oral cavity of Human Immunodeficiency Virus give (HIV)-positive individuals. HPV types are known to be seen more in HIV positive patients, as they are immune-deficient. HPV in saliva of HIV-positive individuals may be associated with high risk for development of HPV-related oral lesions, including malignancy.
Methods: To detect the presence of HPV in HIV-positive patients, 30 saliva samples of sex- workers from redlight street areas in Pune were collected & DNA sequences carried out by polymerase chain reaction (PCR).
Results: The results obtained were negative for HPV in the 30 saliva samples. Thus, indicating that more sample size should be considered for detection of HPV in HIV sero-positive patients for detection of HPV in saliva samples.
Conclusion: This is a non-invasive & prognostic type of study, the results of which will defiantly help in screening, early detection & prevention of HPV related oral cancers in immune-compromised HIV patients by using saliva samples.