Infectious Diseases

Biography

Biography: Hichem Ghaoui

Abstract

Coxiella burnetii infection during pregnancies had been associated with adverse outcomes. We investigated the serological/q PCR evidence of Q fever infection in women' febrile spontaneous abortion in two different gynaecological obstetrics departments in Algiers; which admitting patients from rural/non-rural regions in the Algiers’ suburbs. From April 2014 to November 2015, we worked at 725 pregnant women, within 380 women cases group presented febrile spontaneous abortions, and 345 women pregnant women as control group. Our findings gave a seroprevalence of 0.70 % (3/380) for IgG titers ≥1:100 phase II among the cases group, whereas all the control group sera were IFA negative. In other hand, only 4 from 380 (1.05%) placental samples came back q PCR positive among the control group, then all the other placental samples were q PCR negative for the control group. Few serological studies have concluded results that are consistent with our own, namely Nielson and Dominique who reported a seroprevalence of 1.2%, 0.27% respectively among women with spontaneous abortions included in their studies. q PCR came back with 1.05% positive to both C. burnetii IS1111 and IS30a for the cases group, while the entire control group had q PCR negative. Th is prevalence is not high but better than that obtained by Joanne, Langeley, Carcopino and Quijada, where the q PCR was negative for all placental samples. Seroprevalence of 0.70% and 1.05% of q PCR positive for Coxiella burnetii, this allows us to say that there is a relationship between Coxiella burnetii infection and women’ febrile spontaneous abortion in Algiers; to the rigour of the sampling done in our study. Finally, we would like to follow up this study on a higher sampling of other regions in Algeria in order to highlight a clear picture of Coxiella burnetii infection in women spontaneous abortions.