5th International congress on Infectious Diseases
King's College London
Title: Bovine spongiform encephalopathy (mad cow disease) is probably caused by Bovine spongiform encephalopathy (mad cow disease) is probably caused by Acinetobacter bacteria and not by prions
Biography: Alan Ebringer
Previous studies have shown that there is molecular mimicry between Streptococcus and cardiac collagens in rheumatic fever. In early 1990’s the British government asked whether there was a role for molecular mimicry in bovine spongiform encephalopathy (BSE), also known as mad cow disease. A cursory review of the literature showed that molecular mimicry was present between the soil and nasal microbe Acinetobacter and myelin, the covering of nerves. The government, through DEFRA (Department of Environment, Food and Rural Affairs) then gave a £250,000 grant to King’s College and access to BSE materials to investigate this problem. A pilot study showed that elevated levels of antibodies to the soil and nasal microbe Acinetobacter was found in 29 BSE animals compared to sera from 76 control animals (p<0.001). A second larger study involving 128 BSE compared to 127 controls, confirmed that elevated levels of antibodies to Acinetobacter were present in BSE animals (p<0.001) but not to 6 other bacteria. It appeared that feeding cattle with abattoir materials (meat-and bone meal) caused either contamination with Acinetobacter or with prions and the government banned the use of meat-and-bone meal supplements which led to the disappearance of BSE in British cattle. However a review of the definition of transmissible spongiform encephalopathies (TSE) revealed that the Pasteur Effect, namely the production of experimental allergic encephalomyelitis (EAE) in experimental animals had not been considered when injecting saline brain homogenates in BSE research studies. The bio-assay is based on a wrong assumption that injecting saline brain homogenates will not cause damage to the healthy, test experimental animals. The concept that prions are infectious particles may require revision.